P25.04: Stillbirth and fetal growth restriction from umbilical artery and ductus venosus diastolic waveform assessment: a systematic review and meta‐analysis

Abstract

To assess the risks of stillbirth in early growth restricted fetuses with absent/reverse end-diastolic velocity in umbilical artery (UA) or ductus venosus (DV). We conducted a literature search to identify relevant studies that provided data on early growth restricted fetuses requiring delivery before 34 weeks, with information on stillbirth rate and the presence of absent/reverse end-diastolic velocity in the UA or DV. Both fixed and random effects models were applied. Between-study heterogeneity was assessed using the X2 (Cochrane Q), t2 and I2 statistics. Publication bias was evaluated and quantified by Egger method. A total of 35 studies were included in this analysis. The overall prevalence of stillbirth was 0.05%. Twenty-five studies reported a higher risk of stillbirth in UA waveform analysis. OR under random effects model was 7.32 (p<0.001) with no heterogeneity between them (t2=0.15). Publication bias through Egger k-coefficient was not significant (p=0.58). Fourteen studies showed an increased risk of stillbirth in DV analysis. OR under random effects model was 11.95 (p=0.001). Q statistic of 23.10 (p=0.03) and 46% I2, suggests the presence of heterogeneity throughout publications. Egger k-coefficient method of -1.18 (p=0.283) depicts absence of publication bias. Supporting information can be found in the online version of this abstract Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.