P248 Antimicrobial activity of dry powder liposomal loaded rifampicin against Mycobacterium abscessus complex respiratory isolates

Abstract

Non-tuberculous mycobacteria (NTM) infection is becoming increasingly prevalent in people with cystic fibrosis (pwCF) and is difficult to treat due to resistance to many antibiotics. Furthermore, infections caused by Mycobacterium abscessus complex (MAC) are more likely to result in a decline in lung function in pwCF than other NTM species. Oral rifampicin is used in multidrug treatment regimens for NTM infections but its use is associated with development of systemic side-effects. The aim of this study was to determine the activity of liposomal loaded rifampicin against mycobacterium abscessus complex clinical respiratory isolates.