Abstract
Necrotising enterocolitis (NEC) is one of the most unpredictable and devastating diseases in premature infants. It is a big and costly problem especially for infants who are born with very low birth weight (VLBW).
Highlights
Necrotising enterocolitis (NEC) is one of the most unpredictable and devastating diseases in premature infants
Case patients were defined according to NeoKISS as very low birth weight (VLBW) neonates who had clinical symptoms of necrotising enterocolitis (NEC)
Data on potential risk factors which occurred during pregnancy and hospitalization in NICUs, results of microbiological tests and antibiotic treatment were gathered in the year 2009
Summary
The study covered 910 children with VLBW hospitalized in six neonatal intensive care units in Poland. Case patients were defined according to NeoKISS as VLBW neonates who had clinical symptoms of necrotising enterocolitis (NEC). Data on potential risk factors which occurred during pregnancy and hospitalization in NICUs, results of microbiological tests and antibiotic treatment were gathered in the year 2009. Two kinds of indicators were used for the description of antibiotic usage: the duration of treatment (days of treatment, DOTs) expressed in days and the defined daily dose (DDD), according to the ATC/DDD system. 2.9 DDDs of antibiotics were used for treatment of NEC and total treatment duration was 1,437 days; the average use of drugs in this group amounted to 0.47 DDD or 23.18 days per case. Level of antbiotic usage was analyzed with correlation to microbiological tests performed and it was non-significantly greater in the group of children with NEC in whom the tests were done
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