P240 Lower levels of bacterial aerobic respiration in sputum from people with cystic fibrosis with chronic lung infection

Abstract

Bacterial aerobic respiration has recently been related to the outcome of antibiotic treatment in experimental studies, but clinical relevance of the levels of bacterial aerobic respiration remains to be evidenced. Therefore, we hypothesized that bacterial aerobic respiration is lower in sputum from people with cystic fibrosis (pwCF) and chronic lung infection, where clinical cure is difficult and rare, than in sputum from patients with acute lower respiratory tract infections (aLRTI), where clinical cure is frequent.