Abstract
Clinical Institute. Among them 237 patients had diarrhea: ulcerative colitis (UC) 116 patients, Crohn’s disease (CD) 38, chronic pancreatitis (CP) 58, others 26 (IBS, coeliac disease, colon cancer). All UC and CD patients received AB in the past three months. Other patients were not treated with AB. Clostridium difficile toxins were detected in 93 patients (39%): in UC group 37% (43 pts), in CD group 31.5% (12 pts), in CP group 36% (21 pts), in others 65% (17 pts). In all patients, after taking vancomycin or metronidazole diarrhea disappeared or greatly diminished in intensity. Conclusions: Thus, in patients of gastroenterology department a high frequency of diarrhea associated with CD-I (39%) not only due to AB was observed. This fact usually not taken into account when examining patients have pathogenetic mechanisms of diarrhea in the primary disease. We believe that the detection of Clostridium difficile toxins must be mandatory included in the algorithm of examination of patients with diarrhea regardless of the primary diagnosis. Frequency of CD-I was not differed in UC, CD and PC patients (about 31 37%), but was significantly higher in other patiens with diarrhea.
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