Abstract
Previous studies have reported conflicting results about the prevalence of seizures in AD, and few epidemiological studies in the Asia have been found. We examine the demographic, clinical characteristics and the incidence for seizures with AD patients compared to non-AD patients in a prospective, longitudinal, community-based cohort with long follow-up. The data was collected from National Health Insurance Service-National Elderly cohort(NHIS-elderly) Database to define patients with AD from 2004–2006 based on having KCD code G30, F00. We performed a 1:5 case-control matched analysis using propensity score matching, which were based on age, sex and household income. We conducted Cox proportional hazards regression analysis to estimate the risk of epilepsy in AD. In the cohort study, the patients with AD have higher chances for epilepsy than those without AD. The Hazard ratios for epilepsy with AD are 2.773(95% CI: 2.515-3.057). The study also shows that the gender male, comorbidities such as hypertension, hyperlipidemia, diabetes, and chronic kidney disease increases the risk of developing epilepsy. Patients have 1.527 (95% CI: 1.375–1.695) times higher mortality rate when epilepsy occurred in the AD group than in the control group. Out data show that AD significantly has higher risk for the development for epilepsy.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
