P227. Polygenic Risk for Depression is Associated With Depressive Symptoms and Suicide Attempts and Interacts With Adverse Childhood Environments to Predict Decreased Dentate Gyrus Structure in Offspring at Family Risk for Depression

Milenna Van Dijk,Irina Pokhvisneva,Sachin Patel,Jiook Cha,Marc J Gameroff,Jonathan Posner,Michael J Meaney,Myrna M Weissman,Patricia Pelufo Silveira,Ardesheer Talati

doi:10.1016/j.biopsych.2022.02.461

P227. Polygenic Risk for Depression is Associated With Depressive Symptoms and Suicide Attempts and Interacts With Adverse Childhood Environments to Predict Decreased Dentate Gyrus Structure in Offspring at Family Risk for Depression

Milenna Van Dijk, Irina Pokhvisneva + Show 8 more

https://doi.org/10.1016/j.biopsych.2022.02.461

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Journal: Biological psychiatry

Publication Date: Apr 28, 2022

Affiliation: Columbia University, McGill University, Douglas Mental Health University Institute, Seoul National University, New York State Psychiatric Institute, Duke University, Singapore Institute for Clinical Sciences

#Polygenic Risk For Depression #Risk For Depression + Show 8 more

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Abstract

Rodent and human studies suggest the hippocampal dentate gyrus (DG) region is important for susceptibility to depression. We showed that humans at family risk for depression have decreased DG structure, which predicts future, but not current or past, depressive symptoms. Here we elucidate genetic and environmental mechanisms underlying our previous findings of decreased DG structure in offspring at risk for depression.

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