P223 Image-guided sentinel lymph node detection using near-infrared fluorescence in breast cancer

Abstract

Goals: To evaluate the usefulness of color charge coupled device (CCD) camera system (HyperEye medical system:HEMS), for the intraoperative detection of sentinel lymph nodes (SLN) in breast cancer (BC) patients. Methods: Intraoperative detection of SLN was performed using conventional blue dye technique combined with HEMS for mapping of SLNs. Indigo carmine (blue dye) mixed with Indocyanine green (ICG) was injected via the subareolar plexus, the search of SLN was guided by HEMs for stained lymphatic channels leading to stained LNs. All bright LNs with lighting near-infrared fluorescence and LNs at the end of a lymphatic channel are removed and designated as SLNs. Results: SLN identification was successful in 140 of 144 patients (detection rate: 97.3%). There were four false-negative cases in 144 patients (2.8%). After a median follow-up of 2.5 years none of the patients presented with axillary recurrence. No severe adverse events were observed. Conclusion: HEMS provides color imaging and that recognizes the lymphatic mapping and the location of SLN without the problem of a limited irradiation. This technique might be safety and effective in SLN identification. Disclosure of Interest: No significant relationships.