Abstract
s of the 4th Congress of ECCO the European Crohn’s and Colitis Organisation S99 7.3 (3.4 17.5) mmol/L vs. 10.5 (4.9 22.5) mmol/L in women and 7.4 (4.0 23.9) mmol/L vs. 12.9 (6.7 36.1) mmol/L in men, respectively (p 17.1mM, a phenotypic sign of Gilbert syndrome) was more than four times lower in CD patients as compared to controls (OR [95%CI] = 0.24 [0.11 0.56]; p 1%, deviated from Hardy-Weinberg equilibrium pHWE > 0.01 in the control sample. Assessment of all SNPs and single-marker association analysis were performed using the software program Haploview 4.0. Results: Single-marker analysis revealed marginal associations between IBD and genetic variants from category (2) and (3): CD and rs17419032 (locus: 1q32.1; p = 4.96×10 2) and rs9993022 (locus: 4q13.1; p = 4.78×10 2); UC and rs10883365 (gene: NKX2 3; p = 2.67×10 2), rs17419032 (locus: 1q32.1; p = 3.44×10 2), rs12529198 [gene: LYRM4; p = 3.22×10 2, OR = 0.37 (95%C.I.: 0.15 0.93)] and rs9895062 [gene: STX8; p = 9.64×10 3, OR = 0.34 (95%C.I.: 0.16 0.78)]. Conclusion: Our study has revealed associations between both subtypes of IBD and five markers reported by the Parker et.al. study. As the sample set is small study results represent just the tendency of the allele frequencies distribution in Lithuanian population and no general conclusions can be drawn.
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