P2-221: Daytime hypersomnolence on the multiple sleep latency test in patients with dementia with Lewy bodies

Abstract

ods: CSF and plasma were gathered from 29 patients with DLB, 174 with AD and 90 with AD with minor vascular components. All patients who had completed a full investigation were selected consecutively from patients referred to a specialist clinic. In addition, cerebrospinal fluid and plasma were gathered from 51 healthy volunteers. Total concentrations of Mg, Ca, Mn, Fe, Cu, Zn, Rb, Sr, and Cs in cerebrospinal fluid and plasma were determined for all subjects. Results: Patients with DLB had significantly increased calcium and magnesium levels in their CSF compared to all other investigated groups (p 0.001). Mn, Fe, Cu, Zn, Cu, Rb , and Sr concentration in CSF did not differ between DLB patients and the other groups. Furthermore, a combination of CSF-Mg and CSF-Ca could distinguish DLB from AD with a sensitivity of 93% and a specificity of 85%. Cu levels in both CSF and plasma and Ca levels in plasma tended to be higher in DLB compared with the other groups, but these trends failed to reach significance after correction for multiple comparisons. Conclusions: The increased Ca and Mg concentrations in the CSF of DLB patients may be an important factor in the pathogenesis of DLB. Furthermore, determination of CSF-Mg and CSF-Ca concentration may be a valuable tool in distinguishing DLB from AD.