P22.12: Antenatal diagnosis of amniotic band syndrome-case report

Abstract

Amniotic band syndrome is a set of congenital birth defects believed to be caused by the entrapment of the fetal parts in fibrous bands in utero. Disunion, deformation, malformation, clefts and constriction bands and amputation of various parts of the body could be seen. It can affect any organ or system and cause a single or multiple defects. We report 6 cases of amniotic band syndrome in the second and trimester of pregnancy. It includes multiple fetal defects. It ranges from hand anomalies, ectopia cordis, congenital transverse deficiency, cleft lip cleft palate, facial cleft. Two cases of ectopia cordis with facial anomalies. 2 cases of isolated limb anomaly includes congenital transverse deficiency, 1 case of multiple limb anomalies and 1 for multiple anomalies including limb, abdominal wall defect, spinal defect, encephalocele and facial anomaly. In our study, the earliest case we diagnose is at 15 weeks. Mean age of the patient is 24 years. Amniotic band syndrome caused a variety of fetal malformations involving limbs, craniofacial region and trunk. It occurs in approximately 1 in 1200 to 1 in 15,000 live births. Occurrence is mostly sporadic. In our case, all are from low risk group. 3D & 4D ultrasound shows multiple amniotic bands floating in the amniotic cavity with 1 of them attached to the fetal part.