P210 Association between Non-Alcoholic Fatty Liver Disease and Related Factors in Patients with Idiopathic Chronic Ulcerative Colitis

Abstract

Abstract Background UC is an immunomodulated inflammatory intestinal disease that can involve systemic or extraintestinal manifestations. Few studies have evaluated the possible association between UC and nonalcoholic fatty liver disease (NAFLD). However, the prevalence of NAFLD among patients with UC has been reported to be higher than in the general population. Objetive: To determine the frequency of NAFLD in patients with UC and the factors associated with the simultaneous presence of both diseases. Methods This was an observational, cross-sectional, relational, and analytical study that included 40 patients with UC. Data on demographics, clinical information, biochemical parameters, endoscopic findings, and histological features were collected for each patient. Disease activity was assessed using the Truelove and Witts scales, Mayo endoscopic scale, and Riley histological index. NAFLD was evaluated using transient elastography (FibroScan®), determining the controlled attenuation parameter (CAP) with a cutoff score of 248 dB/m to define steatosis. Hepatic fibrosis was considered when the measurement exceeded 6.5 kPa. The risk of steatohepatitis was estimated using the FAST index. Data were analyzed using the MyFibroScan® app, selecting "multi-etiology" as a parameter. Statistical analysis was performed using SPSS version 26, calculating correlation coefficients using Spearman's Rho. A value of p < 0.05 was considered significant. Results The clinical and demographic characteristics of the patients are described in Table 1. A positive correlation was found between CAP and Body Mass Index (r = 0.36; p = 0.02). Statistically significant differences were observed between CAP and Truelove and Witts scale (p = 0.02). Differences were also noted between kPa value (p = 0.03) and FAST index (p < 0.001) and the medical treatment used to control UC. No associations or correlations were observed between CAP, kPa, FAST index, and endoscopic or histological severity or other clinical characteristics of the patients. Conclusion The presence of NAFLD in patients with UC may be of metabolic origin, predominantly associated with overweight/obesity, and determined by the clinical-biochemical immunomodulated inflammatory activity of the disease and the concurrent treatment used. These findings highlight the importance of a multidisciplinary approach in the care of patients with UC.