Abstract
Kainic acid (KA) treatment induced neuronal death and apoptosis in murine cerebellar granule cells (CGNs) cultures from both wild-type and knockout p21 −/− mice. There was not statistically significant difference in the percentage of neuronal apoptosis among strains. KA-induced neurotoxicity was prevented in the presence of NBQX (20μM) and GYKI 52446 (20 μM), but not by z-VAD-fmk, suggesting that caspases are not involved in the apoptotic process. Data suggest that p21 WAF/Cip was unable to modulate KA-induced apoptosis in murine CGNs.
Published Version
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