Abstract
Patients with long-lasting aluminium hydroxide-induced macrophagic myofasciitis (MMF) present with diffuse arthromyalgias, chronic fatigue, and cognitive disorder. One hundred five unselected consecutive MMF patients were subjected to neuropsychological evaluation and brain MR imaging (MRI). From descriptive analysis, 64/105 (61%) patients had fronto-subcortical cognitive deficits with pathological results at executive functions and selective attention tests (performances below -1.65 SD). Among them, 24 had pathological results in storage and consolidation functions for episodic verbal memory, and 9 left ear extinction at dichotic listening test, in addition du fronto-subcortical impairment. Remaining 41 patients (39%) displayed performances above pathological threshold in all tests. However, inter-test analysis showed that these patients performed significantly worse to executive functions and attention tests compared to others. None of the patients had instrumental dysfunction. Brain MRI analysis did not show specific features associated with cognitive impairment.
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