P207. Associations Between Neural Reward Response and Anhedonia in High-Risk Adolescents

Abstract

Adolescence exists as a major window of plasticity for higher order cognition, creating vulnerability for disease onset of depression, bipolar, schizophrenia, all which share a key feature in anhedonia. Neuroscience models propose that anhedonia in adults has a basis in neural reward circuitry, but data evaluating these models developmentally in the context of familial risk are fundamentally lacking. We address this gap by examining associations between risk, neural response to reward, and anhedonia.