Abstract
Sleep disturbances are present across all states of bipolar disorder (BD) and highly consequential for treatment. While sleep has been studied in mouse models of mania, still little is known about general sleep disruptions in transgenic mouse models of BD. Ankryin3 (Ank3) is highly implicated in BD through human genetics studies, and Ank3-1b deficient mice exhibit BD-related behavioral phenotypes. However, sleep patterns in this model have not been investigated. Thus, we examined spectral correlates of rapid eye movement (REM) and non-REM (NREM) sleep in Ank3-1b knockout (KO) mice.
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