Abstract
Fatty acid amide hydrolase (FAAH), the anandamide-catabolizing enzyme, is a key determinant of endocannabinoid tone. In line with preclinical and post-mortem findings, our recent positron emission tomography (PET) study with the FAAH radiotracer [C-11]CURB reported reduced FAAH during early abstinence from alcohol in alcohol use disorder (AUD) compared to controls. However, the status of FAAH in AUD during longer abstinence remains unknown. The present study aimed to determine whether FAAH levels recover in individuals with AUD during longer alcohol abstinence.
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