Abstract
Background A previous therapeutic vaccine pilot study based on autologous dendritic cells pulsed with autologous heat inactivated viruses HIV-1 obtained by plasmapheresis, showed a decrease in the plasma viral load in 4 of 12 chronically HIV-1-infected patients [Garcia et al., J Infect Dis. 2005; 191: 1680–1685]. This vaccination strategy required to submit the infected patients to 2 structured treatment interruptions (STI): the first to recover enough viruses to be used as antigen, and the second to assess virological responses after the immunization. We aimed to study the viral variability evolution changes occurring during off therapy period, before and after vaccination.
Highlights
A previous therapeutic vaccine pilot study based on autologous dendritic cells pulsed with autologous heat inactivated viruses HIV-1 obtained by plasmapheresis, showed a decrease in the plasma viral load in 4 of 12 chronically HIV-1-infected patients [García et al, J Infect Dis. 2005; 191: 1680–1685]
We aimed to study the viral variability evolution changes occurring during off therapy period, before and after vaccination
The viral complexity was lower in STOP2 than in STOP1, and there was a trend to decrease amino acid changes and diversity after this therapeutic vaccination
Summary
Study of viral variability evolution in patients submitted to a therapeutic vaccine based on autologous dendritic cells pulsed with autologous HIV-1. Address: 1Retrovirology and Viral Immunopathogeny Laboratory, Hospital Clínic/IDIBAPS-HIVACAT, University of Barcelona, Barcelona, Spain and 2Irsicaixa Foundation-HIVACAT, Hospital Germans Trias i Pujol, Badalona, Spain. Published: 22 October 2009 Retrovirology 2009, 6(Suppl 3):P376 doi:10.1186/1742-4690-6-S3-P376. AIDS Vaccine 2009 Anna Laura Ross Meeting abstracts – A single PDF containing all abstracts in this Supplement is available here. http://www.biomedcentral.com/content/pdf/1471-2105-10-S12-info.pdf
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