P2-438: Amyloid precursor protein–binding protein 1(APP-BP1) is critically required for the cell cycle progression in neural stem cells

Abstract

ease (AD) patients was demonstrated in previous research. Since individuals with Amnestic Mild Cognitive Impairment (A-MCI) are at increased risk of developing AD, it is thus of interest to apply an EL approach to this particular population. Objective: The main goal of the present study was to investigate the efficacy of a memory training program using an EL paradigm compared to a control condition, the errorful (EF) learning, to help A-MCI individuals learn new people’s names. Methods: Twenty individuals meeting Petersen’s criteria for A-MCI were included in the study. Participants were randomized to the EL (n 11) or the EF (n 9) condition, and took part in 6 individual sessions over three weeks. They were trained to learn and recall 5 new face-name associations (first and last names) using the EL or EF paradigm. The program also contained psycho-educational content regarding different aspects of memory functioning. Measures of the trained material together with objective and subjective tests of memory were administered at baseline and post-intervention sessions. Results: Mixed ANOVAs revealed a main effect of time on the capacity to recall the trained material (F(1,18) 60.371, p 0.001). Group effect was however not significant. A significant pre-post effect was also observed on two subscales of the Multifactorial Memory Questionnaire. Participants thus reported a significant higher degree of satisfaction regarding their memory at the end of the program (F(1,18) 9.547, p 0.01) and also a superior self-reported use of mnemonic strategies in everyday life compared to baseline (F(1,18) 14.395, p 0.01). However, there was no group effect. Conclusions: These preliminary results showed overall efficacy of the intervention program, regardless of the condition. However, several factors might explain the absence of significant difference between the two groups such as both received a psycho-educational intervention. In addition, explicit memory and general cognitive functioning are more preserved in A-MCI than in AD, thus probably making any intervention in MCI more efficacious than in AD. Long-term follow-up of these data will permit to verify if the training gains will be maintained over time, and similarly, between the two conditions.