Abstract
Background The aim of this study was to determine the collagenase-1 also named metalloproteinase-1 (MMP-1) and its tissue inhibitors, TIMP-1 and TIMP-2 in patients with metabolic syndrome (MetS) and to understand their relationship with the elevated blood pressure. Methods 199 patients with MetS and 150 control subjects were required in the Rabta hospital of Tunis. MMP-1, TIMP-1 and TIMP-2 levels were determined in citrate plasma by ELISA methods. Results Levels of MMP-1 decreases significantly in MetS patients compared to control group (p Conclusions The decrease of the MMP-1 is associated with a significant increase of its specific inhibitor when blood pressure is high in patients with MetS. These results demonstrate the disruption of the balance between MMPs and their inhibitors and a matrix remodeling that may explain the pathophysiological changes in MetS and the elevated cardiovascular risk.
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