P2.17-08 Ethanol Release Heat-Generating Polymer for Focal Therapy of Small Lung Cancers Under Open MRI

Abstract

Recently, the lung cancer lesions of small GGO lesions are increasingly found. Such an elderly person who found a small cancer lesion reveals low durability for surgery and sometimes has many medical complications around chronic diseases. therapy of micro lung cancers under open MRI and developed medical devices. We have synthesized low viscosity silicon material which absorb a trace amount of water, generates heats and indurate in a few minutes. We have adjusted the concentration of titanium catalyzer, and a fine image can be visualized under CT imaging equipment and 0.3T open MRI. In animal experiments, rat lungs are divided in 10-micron unit CT imaging, the indurated conditions of thermosetting resin in the lungs was analyzed as 3D DICOM image data and 0.3T MRI DICOM images of Hitachi Corporation. We have developed non-artifact metallic needle as a biopsy needle under open MRI circumstance. It was confirmed that the indurated resin was hardened three-dimensionally without cracks, the surrounding cells were damaged, the resin can be detected with CT. The micro resin can be detected with 0.3T Open MRI. We have succeeded in synthesizing “Ethanol Release Heat-Generating Polymer” for focal therapy of micro lung cancers and archiving non-artifact medical devises under MRI. The idea of this research is Japanese patent JP6447858. This work was PCT patent pending JP2017/025044 in US and China and supported by JSPS KAKENHI Grant Number JP15K15517 and 18H05377.