P2.16-23 Focal Therapy for Small Lung Cancer with Ethanol Release Heat-Generating Polymer

Abstract

As opportunities to take high resolution CT images of lungs by lung cancer screening increase, the lung cancer lesions of small GGO lesions are increasingly found. Such an elderly person who found a small cancer lesion reveals low durability for surgery and sometimes has many medical complications around chronic diseases. In this study, we have synthesized “Ethanol Release Heat-Generating Polymer”, for focal therapy of micro lung cancer. We have synthesized low viscosity silicon material which absorb a trace amount of water, generates heats and indurate in a few minutes under industry-academia collaboration. We have adjusted the concentration of titanium catalyzer, and a fine image can be visualized under CT imaging equipment. We perfumed rat experiments that 0.03 mL of injected viscous liquid resin was injected into rat lungs under micro surgery. Histological images of alveolar epithelial cells inside and around the resin injection area were examined by HE staining. Also, in order to analyze three-dimensionally whether the target site is surrounded without cracks, we used the micro CT apparatus of Shimadzu Corporation. Rat lungs are divided in 1 micron unit CT imaging, the indurated conditions of thermosetting resin in the lungs was analyzed as 3D DICOM image data. Alveolar cells close to the resin were denatured. According to the 3D micro CT views of the indurated resin in the rat lung (Fig), it was was hardened three-dimensionally without cracks, the surrounding cells were damaged. The CT value of the resin itself was high, and it was distinguished as white induration from the cell components of the lung. We have succeeded in synthesizing “Ethanol Release Heat-Generating Polymer” for focal therapy of micro lung cancers. This work was PCT patent pending JP2017/025044 and supported by JSPS KAKENHI Grant Number JP15K15517.