Abstract
Chemoradiation is the standard treatment for patients with unresectable locally advanced non-small cell lung carcinoma (LA-NSCLC), however, treatment resistance is commonly developed and the prognosis still poor, since no reliable biomarkers are available for patient stratification. In this context, autophagy up-regulation has been postulated as a mechanism of resistance to chemoradiation and we presented, at the IASLC 2020 Lung Cancer Hot Topic: Liquid Biopsy and the AACR: Radiation Science and Medicine 2021, autophagy in circulating tumor cells (CTCs) and levels of specific extracellular vesicle (EV) miRNAs can be correlated and evaluated as promising minimally invasive predictive biomarkers.
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