P2-128 - Successful Readministration with Oxaliplatin in Patients with Allergy to Oxaliplatin in Colorectal Cancer Patients

Abstract

ABSTRACT Background Oxaliplatin is an important drug of the treatment of colorectal cancer. It is known that some patients exhibit to be allergic to oxaliplatin during repeated treatment. As a result, administration of oxaliplatin is forced to be discontinued while there is a therapeutic effect. We report four patients successfully continued with oxaliplatin containing regimen after development of allergic symptom to the same drug by changing the method of drug administration. Methods thirty-seven colorectal cancer patients were treated with a oxaliplatin containing regimen between October 2011 and December 2011. Four patients allergic to oxaliplatin received allergy treatment protocol. The allergy treatment protocol in mFOLFOX6 regimen is different from the usual treatment protocol in following points: premedication with dexamethasone 13.2 mg IV, diphenhydramine 50 mg PO and famotidine 20 mg IV before oxaliplatin and oxaliplatin infusion in 4 h in the allergy treatment protocol (premedication with dexamethasone 6.6 mg IV, unpretreated with diphenhydramine and famotidine and oxaliplatin infusion in 2 h in the usual treatment protocol). Results Four patients allergic to oxaliplatin in the usual treatment protocol avoided the allergy after oxaliplatin readministration by the use of the allergy treatment protocol. Conclusions The allergy treatment protocol in mFOLFOX6 regimen is effective in colorectal cancer patients allergic to oxaliplatin.