Abstract
Abstract Background Systemic inflammation may influence survival in women with breast cancer. Both the platelet lymphocyte ratio (PLR) and the neutrophil lymphocyte ratio (NLR) have been shown to be associated with survival in a number of solid tumours. The aim of this study was to assess the role of PLR and NLR in survival of women with early breast cancer. Methods: Women diagnosed with early breast cancer at two centres between 2003 and 2006 were included. All women had measured white cells, neutrophils, lymphocytes and platelets. NLR and PLR were calculated. Cox regression survival analysis was performed with breast cancer specific survival used as the primary end point. Significant associations of NLR and PLR with pathological variables was assessed using the Chi squared test. Results: 707 women were included with a median follow up of 3.7yrs. On univariate analysis neither NLR (HR 1.08, 95% CI 0.66−1.79) or PLR (HR 0.96, 95% CI 0.58−1.59) were significantly associated with breast cancer specific survival. An increased PLR was found to be associated with significantly fewer grade 1 tumours (P<0.05) but no other significant associations with pathology was demonstrated for either PLR or NLR. Conclusions: This study would suggest that the NLR and PLR are not prognostic of survival in women with early breast cancer. Citation Information: Cancer Res 2011;71(24 Suppl):Abstract nr P2-12-30.
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