P2.11-37 Low-Dose CT Lung Screening: Analysis of Risk Factors Related to Lung Cancer

Abstract

LDCT has been increasingly accepted as an efficient screening method for lung cancer detection and mortality reduction in high-risk populations. Screening data based lung cancer risk factors analysis is supposed to benefit identifying high-risk population of lung cancer. The aims of this study are to provide data support for identifying high-risk groups of lung cancer and to improve the effectiveness of LDCT lung cancer screening. Subjects consisted of 5366 asymptomatic and voluntary participants (includes 2762 males and 2604 females) aged 40-87 years old, who received LDCT in Cancer Hospital, Chinese Academy of Medical Sciences between Jan 1st, 2014 and Dec 31st, 2017. Participants finished questionnaires relevant to risk factors and were provided Low-dose CT scans. The LDCT Radiological results were interpreted according to the I-ELCAP lung Screening Protocol. Multivariate logistic regression examined associations of risk factors within Age, Sex, Smoking status, Second-hand smoking status, COPD, Asthma, Family history of lung cancer, History of tuberculosis, Occupational exposure and Diabetes. 389 of the 5366 participants had a positive (including lung cancer) screen with LDCT, 26 participants were pathologically confirmed lung cancer. Multivariate logistic regression showed that age and smoking (previous smoking and current smoking) were risk factors related to lung cancer and positive nodules. There was no risk factor in distinguishing between lung cancer and positive nodules (excluded lung cancer). Stratified by age, Multivariate logistic regression did not identify any risk factor related to lung cancer and positive nodules in 40-49 years old group, while 3 risk factors were identified in ≥50 years old group (age, smoking, and history of tuberculosis).View Large Image Figure ViewerDownload Hi-res image Download (PPT) • Age, smoking are risk factors related to lung cancer and positive nodules. • ≥50 years old with a history of smoking or tuberculosis may be a high risk group for lung cancer in China.