P2-077: Comparison of manual and automated determination of hippocampal volumes in MCI and older adults with cognitive complaints

Abstract

of language and semantic memory testing. Results: As a group, patients with progressive fluent aphasia demonstrated prominent left-greater-thanright temporopolar thinning, while patients with progressive non-fluent aphasia demonstrated thinning in left-greater-than-right inferior frontoinsular cortex. Yet there were notable individual differences in anatomic abnormalities that corresponded with differences in language, cognition, and behavior. Within the group of patients with fluent aphasia, the patient with the most prominent semantic impairment had the greatest degree of thinning of the left temporopolar cortex (31%) as compared to a group of controls; this patient also had prominent abnormalities of affective and social behavior, which may relate to prominent right temporopolar thinning (29%). Within the group of patients with non-fluent aphasia, the patient with non-fluent progressive aphasia and apraxia of speech had thinning not only in left inferior frontal gyrus (19%) but also in ventral precentral gyrus (26%) and supplementary motor area (24%). Conclusions: Quantitative cortical thickness analysis of MRI data shows promise in applications to individual subjects with progressive aphasia for localizing regional cortical thinning that may underlie specific language and behavioral abnormalities. Further investigation will determine whether this approach will be helpful in more detailed subtyping of these patients, in differential diagnosis, or as an imaging biomarker for monitoring the effects of potential future therapies. Supported by NIA R01-AG29411, K23-AG22509, NCRR P41RR14075, U24-RR021382, and the MIND Institute.