P2.01-22 Increased Incidence, Morbidity and Mortality Rates for Lung Cancer in Women in Brazil Between 2000 and 2014

Abstract

Introduction: Lung cancer is the principal cause of death from cancer worldwide. However, little is known of its epidemiological and histological profile and of the incidence and mortality rates in Brazil according to sex. Objectives: To evaluate the incidence, morbidity and mortality rates of lung cancer in Brazil from 2000 to 2014, as well as the epidemiological and histological profile of the disease. An analytical, cross-sectional study was conducted using three types of sources of secondary data: population-based cancer registries, hospital-based cancer registries and the national mortality database. The incidence rate in women increased from 7.92/100,000 in 2000 to 9.12/100,000 in 2012, while mortality increased from 6.02/100,000 in 2000 to 8.29/100,000 in 2014. In men, the incidence decreased from 23.40/100,000 in 2000 to 18.47/100,000 in 2012 and mortality also fell from 16.12/100,000 to 15.11/100,000 in 2014. There was a reduction in the male-to-female ratio from 2.54 in 2000 to 1.46 in 2014. Women tended to be younger (p<0.001), black (p<0.001), non-smokers (p<0.001), to have adenocarcinoma or small-cell lung cancer (p<0.001), and to have metastatic disease (p<0.001). In addition, the time between diagnosis and the start of cancer treatment was longer in women (p<0.001). In relation to treatment, women were more likely to have undergone chemotherapy, surgery or surgery in combination with chemotherapy (p<0.001) and to have response to the initial treatment (p<0.001). An increase was found in the incidence and mortality rates of lung cancer in women in Brazil.