P2.01-02 Delivery of Concurrent Extracranial Stereotactic Body Radiotherapy with Osimertinib for Oligoprogressive EGFR Mutated Stage IV NSCLC

Abstract

Osimertinib is a third generation Tyrosine Kinase Inhibitor (TKI) and is considered first line therapy for patients with metastatic Epidermal Growth Factor Receptor (EGFR) NSCLC with exon 19 deletion or exon 21 L858R. Osimertinib has demonstrated improved progression free survival (PFS) and overall survival (OS) compared to first generation TKI’s. However, during the course of their disease many patients develop oligoprogressive disease (OPD): <=3 metastatic lesions with otherwise controlled systemic disease.