P192 Productivity losses in inflammatory bowel disease: A systematic review

Abstract

number of hospitalizations, the body mass index (BMI), the presence of extraintestinal manifestations, the need for transfusion, transfer from another hospital and the frequency of Clostridium difficile infection were also compared and statistically analyzed between the two groups. P< 0.05 was considered statistically significant. Results: The records of 182 UC patients with a total of 276 hospitalizations because of severe relapse of UC were reviewed. 25.3% of the patients underwent colectomy after average disease duration of 10 years. Pancolitis, low hematocrit level and the need for blood transfusion were significantly more common in the colectomy group (p = 0.004 and p = 0.002). The number of hospitalization, disease duration, and a lower BMI value also proved to predispose to surgery (p = 0.004, p = 0.049 and p = 0.027). Women, younger age at the diagnosis and thrombocytosis showed borderline significance in the risk for colectomy. No association was found between the need for surgery and total parenteral nutrition, Clostridium difficile infection, transfer from another hospital, and electrolyte disturbances. None of the inflammatory laboratory parameters were associated with colectomy. Smoking and the presence of extraintestinal manifestations also did not predispose to surgery. Conclusions: Our results suggest that severe UC patients with pancolitis, anemia, longer disease duration and frequent hospital admissions have a higher likelihood of requiring colectomy.