P19. Comparing the pregnancy outcome in nuliparas both with and without microalbuminuria at the end of the second trimester of pregnancy

Abstract

Question Poor pregnancy outcome and complications during pregnancy such as pre-eclampsia, preterm delivery, preterm premature rupture of membranes (PPROM) and intra uterine growth restriction (IUGR), are very important and the finding of new methods for their prediction has always been a matter of serious concern. The purpose of the present study is to evaluate the poor pregnancy outcome in nulliparas who had microalbuminuria at the end of second trimester of their pregnancy. Methods The study was conducted as a prospective cohort study on 490 nulliparous women who were at the end of the second trimester of pregnancy. Urine tests for albuminuria and creatinine measurements were performed in all women and an albumin creatinine ratio (ACR) was calculated according to milligram per gram. The women were then divided into 3 categories of severe, moderate and mild microalbuminuria according to the ratio.The women with microalbuminuria (case group) and without microalbuminuria (control group) were monitored to the end of their pregnancy and compared for preterm labor, preeclampsia, intra uterine growth restriction (IUGR) and preterm premature rupture of membranes (PPROM). Results Preterm labor [21 (55.26%) cases VS 65 (14.38%), P = 0.001], preeclampsia [19 (50%) cases VS 39 (8.62%) cases, P = 0.0001], IUGR [15 (39.47%) cases VS 30 (6.63%) cases, P = 0.001] and PPROM [11 (28.94%) cases VS 47 (10.39%) cases, P = 0.001] showed more in the case group than control group. Gestational diabetes did not show any significant difference between the 2 groups. Using multivariate logistic regression analyses, microalbominuria showed an increased risk for PTL [Adjusted OR (95% CI) = 2.4 (1.1–5.5), P = 0.03] and preeclampsia [Adjusted OR (95% CI) = 9.5 (4.6–19.3), P = 0.000]. Conclusion Preterm labor, precclampsia, IUGR and PPROM were higher in the women who had microalbuminuria at the end of the second trimester of their pregnancy.