Abstract
Background Co-stimulatory molecules play a critical role in the development of cellular immunity. Understanding how costimulatory pathways interact and influence the immune response is critical for the generation of an effective HIV vaccine. We evaluated the ability of intravenous administration of blocking monoclonal antibodies (mAb) directed against the negative co-stimulatory molecule, CTLA-4, and an agonist mAb directed against the positive co-stimulatory molecule, 41BB, to augment intramuscular SIV DNA immunizations. We then tested the ability of these responses to impact a SIVmac251 challenge.
Highlights
Co-stimulatory molecules play a critical role in the development of cellular immunity
We evaluated the ability of intravenous administration of blocking monoclonal antibodies directed against the negative co-stimulatory molecule, CTLA-4, and an agonist mAb directed against the positive co-stimulatory molecule, 41BB, to augment intramuscular SIV DNA immunizations
On the day of each immunization, as well as two days later, macaques were infused with 10 mg/kg of an anti-41BB mAb, an anti-CTLA-4 mAb, both, or without antibodies
Summary
Modulation of vaccine induced responses through CTLA-4 and 41BB enhances protection in macaques following SIVmac251 challenge. Address: 1Pathology, University of Pennsylvania, Philadelphia, PA, USA, 2Bioqual, Inc., Rockville, MD, USA and 3Bristol-Meyers Squibb Company, Princeton, NJ, USA. Published: 22 October 2009 Retrovirology 2009, 6(Suppl 3):P369 doi:10.1186/1742-4690-6-S3-P369. AIDS Vaccine 2009 Anna Laura Ross Meeting abstracts – A single PDF containing all abstracts in this Supplement is available here. http://www.biomedcentral.com/content/pdf/1471-2105-10-S12-info.pdf
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