Abstract
Background Utilizing plants to produce pharmaceutical products, including antigens for AIDS, is a new way to produce vaccines. HIV-1 Tat plays a major role in viral replication and is essential for AIDS disease development making it an ideal vaccine target provided that both humoral and cellular immune responses are induced. Previous attempts to express Tat in tomato only reported successful humoral immune responses induction while certain physiological abnormalities were also observed in tomato which would be detrimental to furthering plant-based HIV vaccine development. In this study, an in-depth understanding of the effects of Tat expression in tomato and its immunogenicity was determined.
Highlights
Utilizing plants to produce pharmaceutical products, including antigens for AIDS, is a new way to produce vaccines
Potential of an HIV-1 Tat fusion protein expressed in tomato as a plant-based HIV vaccine
HIV-1 Tat plays a major role in viral replication and is essential for AIDS disease development making it an ideal vaccine target provided that both humoral and cellular immune responses are induced
Summary
Potential of an HIV-1 Tat fusion protein expressed in tomato as a plant-based HIV vaccine. Address: 1Department of Molecular and Cellular Biology, Nagoya City University Graduate School of Medical Sciences, Nagoya City, Japan, 2Tsukuba Primate Research Center, Tsukuba, Japan, 3Tsukuba Primate Research Insitute, Tsukuba, Japan and 4University of the Philippines Los Banos, Los Banos, Philippines. Published: 22 October 2009 Retrovirology 2009, 6(Suppl 3):P336 doi:10.1186/1742-4690-6-S3-P336. AIDS Vaccine 2009 Anna Laura Ross Meeting abstracts – A single PDF containing all abstracts in this Supplement is available here. http://www.biomedcentral.com/content/pdf/1471-2105-10-S12-info.pdf
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