P1783 Concealed structural abnormalities detected by 2D speckle tracking strain echocardiography persist post ablation in patients with idiopathic ventricular arrhythmias

Abstract

Abstract Background Idiopathic ventricular arrhythmias (IVA) occurs in patients without overt heart disease. 2D speckle tracking strain echocardiography parameters, including global longitudinal strain (GLS) and mechanical dispersion (MD), have been shown to predict ventricular arrhythmias. It is unclear if the abnormalities are due to structural substrate abnormality, or substrate abnormality consequent to electrical alterations. Aim: We sought to assess whether patients with IVA have impaired left ventricular (LV) strain indices, and if so, whether these persist following successful treatment with radiofrequency ablation (i.e. correction of electrical alteration). Methods: 2D strain analysis was performed (in sinus rhythm) in 23 consecutive patients with IVA (no structural heart disease by cardiac magnetic resonance imaging (MRI); Group A) prior to electrophysiological mapping/ablation, and compared to 23 age and gender matched healthy controls (Group B). Follow up echocardiography and multiday Holter monitoring was performed 12 months post ablation. Results: Baseline characteristics were similar for indexed LV end diastolic volume (EDV) and ejection fraction (EF) (p = 0.1 for both) (Table 1). LV GLS was lower (p = 0.03) and LV MD was increased (p = 0.002) in the IVA group prior to treatment. At follow up, 18 patients (78%) (Group C) remained free of ventricular arrhythmias – in these patients, LV GLS improved and was similar to controls (p = 0.217); however, LV MD remained significantly increased at 12 months compared to controls (p = 0.009). In the 5 patients (22%) (Group D) that continued to have ventricular arrhythmias at follow up, both LV GLS (p = 0.04) and LV MD (p = 0.008) remained significantly impaired compared to controls. Conclusion: Despite demonstrable absence of structural abnormalities with cardiac MRI, 2D strain can detect subtle alterations in myocardial contraction heterogeneity. Furthermore, 12 months post successful ablation treatment, the increase in MD persists. This suggest the presence of subtle substrate abnormality that results in IVA. In uncured patients, both myocardial deformation parameters remain impaired, suggesting the need for close future surveillance of these patients. Long term follow up with greater number of patients is required to further validate these findings. Table 1. Echocardiographic parameters Group Indexed LVEDV (ml/m2) LVEF (%) LV GLS (%) LV MD (ms) IVA (Group A) 55 ± 15 61 ± 5 -19.9 ± 3* 44 ± 12* Controls (Group B) 54 ± 14 64 ± 7 -21.2 ± 2 33 ± 9 Group C 12 months follow up -21.7 ± 3 42 ± 11* Group D 12 month follow up -19.8 ± 2* 43 ± 11* * denotes p < 0.05