Abstract
The incidence of Ulcerative colitis(UC) in Korea is increasing rapidly. Corticosteroids, immunomodulators and biologic agents used in the treatment of UC are risk factors for C. difficile or CMV infection. Until now, concomitant infection with CMV and C. difficile is rarely reported, so here we present 3 cases. A 65-year-old, a 68-year-old and a 46-year- old Korean female with history of ulcerative colitis receiving prednisone and an immunomodulator was diagnosed Clostridium difficile infection and cytomegalovirus infection in stool study and sigmoidoscopic biopsy. They were treated with oral metronidazole, oral vancomycin or fecal microbiata transplantation for Clostridium difficile and treated with intravenous ganciclovir for cytomegalovirus infection. The sigmoidoscopic finding improved and the symptoms also had been relieved. In patients undergoing an IBD flare and receiving immunosuppressive therapy, a test for C. difficile is recommended. In addition, when a patient’s symptoms persist despite appropriate treatment, early endoscopy with tissue biopsies for CMV should be considered. Further studies are required to optimize the treatment of CDI in IBD flare patients.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
