P170 Correlation between health-related quality of life and smartphone-based self-assessment of activity index in patients with ulcerative colitis

Abstract

Abstract Background E-health platform can facilitate remote monitoring of ulcerative colitis (UC) patients. A recent study shows that patient-administered simple clinical colitis activity index (SCCAI) via online correlated well with physician-assessed SCCAI. We evaluated the correlation between the self-administered SCCAI through smartphone and health-related quality-of-life assessment. Methods Clinical disease activity was assessed by the SCCAI and health-related quality of life by the disease-specific, self-administered Inflammatory Bowel Disease Questionnaire (IBDQ). Patients were followed-up over six months. At months 3 and 6, patients completed SCCAI through access to the web-based system (PROscore system) via link sent by text message to the smartphone at the outside of the hospital; within 48 h, patients subsequently completed the questionnaire of IBDQ in the clinic and attending gastroenterologist (blinded to patients’ scores) assessed the in-clinic SCCAI (reference). SCCAI scores were categorized into remission or active disease. Results A total of 157 patients (median age: 41 years; 62% male) contributed with 310 pairs of questionnaires. SCCAI scores by patients inversely correlated well with IBDQ (Pearson’s ρ =0.39). Moreover, linear regression revealed that this correlation persists irrespective of patient age, gender, disease extent, and education status. Correlation of SCCAI scores by patients and physicians was good (Spearman’s ρ =0.36), with 66% agreement for remission or active disease. The negative predictive value for the active disease was 84.3%; the positive predictive value was 41.2.0%. Conclusion In patients with UC, self-administered SCCAI via smartphone showed a good correlation with physician assessed disease activity and the patient’s quality of life. This validated e-health platform may be useful in remote monitoring of UC patients.