Abstract
Background Langerhans cells (LC), skin residential cells, are shown to induce specific CD8+ T cell response upon activation. Targeting vaccine antigens to LC with specific antibodies could elucidate specific CD8+ response. Therefore we propose the intra-dermal injection of mAb specific for C-type lectin Langerin, expressed on LC in epidermis, fused to HIV Gag p24 protein, as type of T-cell based vaccine. The present work emphasizes molecular and cellular immune mechanisms triggered in the skin by intra-dermal vaccination.
Highlights
Open AccessAddress: 1Institute for Emerging Diseases and Innovative Therapies, DSV, CEA, Division of Immuno-Virology, Fontenay-aux-Roses, France and 2Baylor Institute for Immunology Research INSERM U899, Dallas, TX, USA
Langerhans cells (LC), skin residential cells, are shown to induce specific CD8+ T cell response upon activation
Our data suggested that using viral antigens fused to the mAb specific for LC target and bring viral Ag to this cell population in the zone of injection
Summary
Address: 1Institute for Emerging Diseases and Innovative Therapies, DSV, CEA, Division of Immuno-Virology, Fontenay-aux-Roses, France and 2Baylor Institute for Immunology Research INSERM U899, Dallas, TX, USA. Published: 22 October 2009 Retrovirology 2009, 6(Suppl 3):P298 doi:10.1186/1742-4690-6-S3-P298. AIDS Vaccine 2009 Anna Laura Ross Meeting abstracts – A single PDF containing all abstracts in this Supplement is available here. http://www.biomedcentral.com/content/pdf/1471-2105-10-S12-info.pdf
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