P17.05: Relationship between uterine artery Doppler and the risk of stillbirth in our population

Abstract

The aim of this study was to determine the relationship between uterine artery Doppler in the second trimester and stillbirths in routinely screened women in our population through a retrospective study. This is a retrospective study performed between August 2007 and May 2016 in a single obstetric unit. Second-trimester uterine artery Doppler pulsatility indices (PI) at 19 to 22 weeks of gestation were obtained from a cohort of 17765 women following routine gestational controls at our centre. Uterine artery PI examinations were performed . PI>95th percentile was defined as an abnormal Doppler. The 95th percentiles of the mean uterine PI was calculated according to each gestational week. The 36 (0.2%) pregnancy losses were obtained from the hospital computerised maternity database and cross-linked to the Doppler database. From our study group, we obtained 36 stillbirths. Analysis showed that the MoMPI median for stillbirths was 0,9323 while the same parameter for the rest was 0,8705. Likewise the Log (MoMPI) mean for stillbirths -0,1348 while the same parameter for the rest was -0,1862 (p<0,05). Considering that, we didn't obtain any statistically significant differences in PI factors between women who had a stillbirth and women with healthy neonates once we applied the Chi-square and Fisher's exact tests. Although we have obtained an odds ratio of 22 risk of stillbirths in cases of IP>95 against cases of IP<95, this is not statistically significant (p>0.05; 95%CI [0.68-7.20]). We have also performed a logistic regression showing no relationship between uterine artery IP in a continuous way and the stillbirths (OR:1.77[0.60-4.42]). We have not found a statistically significant relationship between uterine artery Doppler PI and stillbirth. Although we found a tendency to have higher PI in patients who finally had a stillbirth, this is not statistically significant. Studies are needed with larger number of cases to find out if this tendency can be significant.