P1683INFLUENCE OF BIOPSY PROGNOSIS ON GRAFT SURVIVAL

Abstract

Abstract Background and Aims Renal transplantation is the best alternative renal replacement option for patients with advanced chronic kidney disease. However, the supply of young donors is limited, and does not cover the demand of patients on the renal transplant waiting list, for this reason are being used older donors and exists a high discard rate of those organs base on pathological results (score) of the preimplant renal biopsy. There are several methods to evaluate the quality of the kidneys and the Kidney Donor Profile Index (KDPI) has acquired special relevance to decide the perform of preimplant renal biopsy. Based on the score, a preimplant renal biopsy is performed, which is decisive in certain cases. However, there is poor evidence to support this decision, which can be described as “conservative,” since there is not enough certainty that there is influence of the preimplant biopsy score score on graft survival. Method 389 biopsies of kidney transplant donors of cadaver donors in brain death and asystole type III were included. Donors in asystole type II, combined and live, were excluded. Samples examined by the same pathologist and in paraffin (no case by freezing). A graft survival analysis was performed based on the results of the renal biopsy (score). Likewise, a multivariate analysis of graft survival was carried out including, in addition to the results of the renal biopsy, results such as the age of the donor and recipient and the KDPI. Results graft survival was compared between two transplant subpopulations in our hospital based on whether a preimplant biopsy was performed. According to the data used there are no significant differences in graft survival between transplants in which biopsy has been performed and those that have not. Conclusion our work shows, as is currently the case in the literature, the absence of influence on the score of the preimplant biopsy score on graft survival.