Abstract
Bipolar disorder (BD) is defined by episodes of mania (appetitive drive for reward and pleasure) alternating with depression, anxiety and reduced appetitive drive. There is strong evidence that distinct neuronal circuits driven by specific cell population in the amygdala are key players in aversive and appetitive behavior. These neuronal populations express selective members of the Wnt pathway, specifically Wnt7a and its downstream regulators. Lithium, a classical mood stabilizer, inhibits GSK3β, one of the Wnt downstream family members.
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