Abstract
Background There are a number of challenges in the development of an effective vaccine for HIV, including stimulation of potent and broad cellular and humoral immune response that can cross protect between strains or clades. We have studied the cellular immune response, using genomics, of a DNA based vaccine that resulted in potent and broad cellular immune responses that suppressed SIV251 replication.
Highlights
There are a number of challenges in the development of an effective vaccine for HIV, including stimulation of potent and broad cellular and humoral immune response that can cross protect between strains or clades
Functional genomic immune profile of SIV DNA vaccines delivered by electroporation and combined with molecular adjuvants
We have studied the cellular immune response, using genomics, of a DNA based vaccine that resulted in potent and broad cellular immune responses that suppressed SIV251 replication
Summary
Functional genomic immune profile of SIV DNA vaccines delivered by electroporation and combined with molecular adjuvants. JD Boyer*1, J Yin, A Dai, S Belisle, L Hirao, R Palermo, D Hokey, J Yan and D Weiner. Address: 1Pathology, UPenn, Philadelphia, PA, USA and 2University of Washington, Seattle, WA, USA * Corresponding author from AIDS Vaccine 2009 Paris, France. Published: 22 October 2009 Retrovirology 2009, 6(Suppl 3):P265 doi:10.1186/1742-4690-6-S3-P265. AIDS Vaccine 2009 Anna Laura Ross Meeting abstracts – A single PDF containing all abstracts in this Supplement is available here. http://www.biomedcentral.com/content/pdf/1471-2105-10-S12-info.pdf
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