P16.15: Subsequent pregnancy outcomes in women with prior pregnancy complicated by both very low birth weight and small for gestational age infant

Abstract

To assess the subsequent pregnancy outcomes in women with prior pregnancy complicated by both very low birth weight (VLBW) and small for gestational age (SGA) infant. Prior pregnacy was complicated by VLBW and SGA infant with singleton pregnancy, normal anatomy and normal fetal karyotype. VLBW and SGA infant was defined as birth weight below 1000 g and as below 10th percentlile according to local standards. Subseqent pregnancy outcome was defined as still birth, neonatal death, extremely low birth weight (ELBW), VLBW, low birth weight (LBW), very preterm birth (VPB), preterm birth(PB), and SGA. Uterine arterial Doppler was recorded in both prior and subsequent pregnancy. There were 21 cases matched with study protocol. In prior pregnancy, 10 cases were complicated by pre-eclampsia and 4 neonates were resulted in neonatal or infantile death. In all cases, uterine arterial doppler showed elevated pulsality index (PI). In subsequent pregnancy, there were 2 still births. 0 neontal deaths, 4 ELBW infants, 5 VPB infants and 11 SGA infants. Nine of 11 cases with elevated uterine arterial PI at mid trimester were resulted in SGA infant. In subsequent pregnancy, birth weight and gestational week were higher than in prior pregnancy. Meanwhile, two of 21 pregnancies were resulted in still birth, ELBWI and VPB. Reccurrent risk of SGA in subsequent pregnancy was 52%.