Abstract
Background Previous comprehensive analysis of HIV-1-specific CTL responses in Caucasian and African cohorts demonstrated that the CTL responses to HIV-1 Gag protein were most dominant ones and they were associated with the control of HIV-1 replication. However, such analysis has not been reported in Asian cohort. In the present study, we performed the comprehensive analysis of the magnitudes and the breadths of the CD8+ T cell responses against the cocktails of 11-mer overlapping HIV-1 Nef, Gag, and Pol peptides in 117 chronically HIV-1-infected Japanese individuals who had not been treated with ART.
Highlights
AIDS Vaccine 2009 Anna Laura Ross Meeting abstracts – A single PDF containing all abstracts in this Supplement is available here. http://www.biomedcentral.com/content/pdf/1471-2105-10-S12-info.pdf
Previous comprehensive analysis of HIV-1-specific CTL responses in Caucasian and African cohorts demonstrated that the CTL responses to HIV-1 Gag protein were most dominant ones and they were associated with the control of HIV-1 replication
We performed the comprehensive analysis of the magnitudes and the breadths of the CD8+ T cell responses against the cocktails of 11-mer overlapping HIV-1 Nef, Gag, and Pol peptides in 117 chronically HIV-1-infected Japanese individuals who had not been treated with ART
Summary
Previous comprehensive analysis of HIV-1-specific CTL responses in Caucasian and African cohorts demonstrated that the CTL responses to HIV-1 Gag protein were most dominant ones and they were associated with the control of HIV-1 replication. Control of HIV-1 by HIV-1 Pol-specific CD8+ T cells in chronically HIV-1-infected Japanese cohort H Murakoshi*1, H Gatanaga2, M Koyanagi1, S Oka2 and M Takiguchi1
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