Abstract
Background Regulatory T cells (Tregs) are potent modulators of immunity and may have an impact on T cell regulation and activation in the setting of HIV-1 infection. However, studies on Tregs in HIV-1 infection have shown divergent results and the exact role of Tregs in HIV-1 infection remains poorly understood. We here investigated Treg frequencies, immune activation and HIV-1 specific immunity in elite controllers (EC) and chronic progressors.
Highlights
Regulatory T cells (Tregs) are potent modulators of immunity and may have an impact on T cell regulation and activation in the setting of HIV-1 infection
We studied the frequency of CD4+CD25+FoxP3+ Tregs in HIV-1 elite controllers (HIV-RNA
We evaluated T cell activation by measurement of CD38 and HLA-DR expression on CD8 and CD4 T lymphocytes
Summary
Regulatory T cell frequencies correlate with T cell activation in chronic HIV-1 infection. Address: Ragon Institute of MGH, MIT and Harvard, Boston, MA, USA * Corresponding author from AIDS Vaccine 2009 Paris, France. Published: 22 October 2009 Retrovirology 2009, 6(Suppl 3):P247 doi:10.1186/1742-4690-6-S3-P247. AIDS Vaccine 2009 Anna Laura Ross Meeting abstracts – A single PDF containing all abstracts in this Supplement is available here. http://www.biomedcentral.com/content/pdf/1471-2105-10-S12-info.pdf
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