Abstract
Background No protective immune response has been identified so far and no HIV-vaccine has yet proven successful. However, some individuals seem to be naturally protected against HIV, or at least less susceptible for HIV transmission. These so called exposed uninfected individuals have been heavily studied in hope to revealing the mechanisms behind the protection. Such information would be highly relevant for any HIV-vaccine design. Our aim was to investigate whether oral exposure of HIV is enough to induce a systemic HIV-1 specific cellular immune response.
Highlights
No protective immune response has been identified so far and no HIV-vaccine has yet proven successful
Our aim was to investigate whether oral exposure of HIV is enough to induce a systemic HIV-1 specific cellular immune response
We show that oral exposure is sufficient to induce systemic HIV-1 specific cellular responses
Summary
Induction of systemic HIV-1 specific cellular immune responses by oral exposure in exposed uninfected partner of discordant couples. Address: 1MTC, Karolinska Insitutet, Solna, Sweden, 2Center for Molecular Medicine, Karolinska Institutet, Solna, Sweden and 3Karolinska Institute, Swedish Institute of Infectious Disease Control, Solna, Sweden. Published: 22 October 2009 Retrovirology 2009, 6(Suppl 3):P231 doi:10.1186/1742-4690-6-S3-P231. AIDS Vaccine 2009 Anna Laura Ross Meeting abstracts – A single PDF containing all abstracts in this Supplement is available here. http://www.biomedcentral.com/content/pdf/1471-2105-10-S12-info.pdf
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