Abstract
Abstract Background and Aims Muscle strength is a solid predictor of outcome for hemodialysis (HD) patients. In this study, our aim is to investigate the relationship between muscle strength and six potential muscle biomarkers including irisin, myostatin, myonectin, antichymotrypsin, urotensin II and insulin-like growth factor 1 (IGF-1). Method The cohort of prevalent HD patients in Tungs’ Taichung MetroHarbor Hospital were participated in our cross-sectional clinical study. The serum muscle markers were determined using standardized enzyme-linked immunosorbent assay methods. The muscle strength was accessed by handgrip strength (HGS) on arm without vascular access before dialysis session. Results A total of 175 patients were enrolled in this study with an average age of 59.2 and among them 84 were males (48.0%). Among the six potentially associated with muscle strength viz HGS, we found that only IGF-1 level (r=0.180, p=0.017) correlated positively with HGS. In the multivariate regression analysis, IGF-1 was also significantly correlate with HGS after adjusted for patients’ demographics [RR (95%CI)=0.091 (0.015-0.167)]. In addition, increased IGF level was correlated positively to irisin levels. Conclusion Our study suggested that IGF-1 was associated with HGS. The role of IGF-1 signaling in the induction of muscle atrophy in uremic patients is not fully understood. Figure Future research is required to obtain more detailed insight and may help to alleviate skeletal muscle atrophy in these patients.
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