P1578: CLINICAL CHARACTERISTICS AND PROGNOSTIC ANALYSIS OF 88 PATIENTS WITH HEMOPHAGOCYTOSIS DETECTED BY BONE MARROW SMEAR

Abstract

Background: The clinical characteristics, laboratory examination and prognostic characteristics of patients with hemophagocytes detected in bone marrow smears were analyzed retrospectively to explore the differences in etiology and prognosis of patients with hemophagocytes detected in bone marrow smears. Aims: To investigate the clinical characteristics, laboratory examination and prognostic characteristics of patients with hemophagocytes detected in bone marrow smears. Methods: A total of 88 patients with hemophagocytosis detected by bone marrow smear in four hospitals were collected, and their clinical data were analyzed. They were divided into two groups: the group meeting the diagnostic criteria of hemophagocytic syndrome (HLH) and the group not meeting the diagnostic criteria of hemophagocytic syndrome (non HLH), and their survival was followed up. Results: Among the 88 patients, 37 patients met the diagnostic criteria for hemophagocytic syndrome (42.05%), 51 patients did not meet the diagnostic criteria (57.95%), 68 patients had fever (77.28%), 37 patients showed splenomegasis (42.05%), 59 patients had cytopenia of 2 series or above (67.05%), Serum ferritin was elevated in 44 cases (50.00%). Etiological analysis showed that 58 of 88 patients were tumor-related (65.91%), including 32 cases of lymphoma (36.36%). 20 cases (22.73%) were infection-related. For the HLH group and the non-HLH group, there was no statistical difference in the proportion of macrophages in bone marrow smears between the two groups, and the phagocytes were white blood cells, platelets, red blood cells, etc. No significant difference was observed between the two groups. Follow-up showed that 18 patients in the HLH group died, with a mortality rate of 48.65%, and 19 patients in the non-HLH group died, with a mortality rate of 37.25%. Summary/Conclusion: Due to the detection of bone marrow hemophagocytes, the diagnostic coincidence rate of HLH is only 42.05%. The main cause of HLH is malignant tumor. However, whether HLH can be diagnosed or not, there is a high mortality. The clinical situation of patients should be evaluated more comprehensively as soon as possible and intervened as soon as possible.