P155 ASSOCIATION OF PRIOR COVID-19 INFECTION AND SYSTEMIC SIDE EFFECTS AFTER COVID-19 VACCINATION IN HEALTHCARE POPULATION

Abstract

There is limited information on risk factors associated with COVID-19 vaccination systemic side effects (SSE). Our study assesses if prior history of COVID-19 infection or close exposure is associated with SSE after COVID-19 vaccination. A survey was emailed to study participants using institutional listservs. Questions included demographics, COVID-19 infection history, any known COVID-19 exposure in household or healthcare settings, side effects experienced after both doses of the COVID-19 vaccines, onset and duration of side effects, and reporting of adverse effects. 538 participants completed the survey. Of those, 520 (97%) participants received the Pfizer vaccine. 49 (9%) reported prior COVID-19 infection. 222 (41%) reported exposure to COVID-19 in household settings and/or healthcare settings. SSE after the first dose of the COVID-19 vaccine were seen in 43% (21/49) of participants with prior COVID-19 infection history vs 25% (121/487) of participants without history of COVID-19 infection (p-value < 0.05). There was no significant difference in SSE after the second dose of the vaccine between groups. There was no significant difference in SSE between participants reporting COVID-19 exposure vs no exposure. Of the secondary outcomes, age and workplace were not significantly associated with increased SSE. Females reported more systemic symptoms after the 2nd dose compared to males (p<0.05). Immediate type reactions were very rare (<1%) and precluded data analysis because of their scarcity in our study population. Prior history of COVID-19 infection was associated with SSE after the 1st dose of the COVID-19 vaccine.