P15 – 2318: Clinical profile and outcome of children with infantile spasms, from a single centre registry study at Concept Paediatric Neurology Centre, Ahmedabad, India

Abstract

Objective The aim was to evaluate clinical characteristics along with response to therapy in children with infantile spasm at a tertiary level paediatric neurology centre. Methods An observational, single centre registry study was conducted over 36 months of span. Total 95 children up to 10 years of age, seen at Concept Paediatric Neurology Centre were studied. In all cases detailed history regarding time of onset and type of spasm, birth history, family history, psychomotor development, relevant investigations and medications were recorded in the study. Follow up study was done for upto 2 years. Records were analysed by descriptive statistical methods. Results Out of 95 children enrolled, 64 (67.4%) were males and 31 (32.6%) were females. Out of these, 24 (25.3%) children were less than 6 months of age, 24 (25.3%) were between 7–12 months, 22 (23%) were between 13 and 24 months, 19 (20%) were between 25 and 60 months and 6 children (6.3%) were more than 5 years of age. History of neonatal admission was present in 54 (56.8%) children. Family history of seizures was present in 14 (14.8%) children and history of consanguinity was present in 6 (6.3%) children. The main presenting complaint was typical spasms in 45 (47.4%) followed by convulsion in 16 (16.8%), developmental delay in 16 (16.8%), convulsion with spasms in 14 (14.7%). The most common abnormal finding was microcephaly in 48 (50.5%) children. 80 (84.2%) children had hypsarrhythmia in EEG, 10 children had generalised seizure discharges and 4 (4.2%) patients had normal EEG. All of them were given Sodium Valproate and Vigabatrin/ACTH injection. Follow up data showed that outcome had strong correlation with etiology and time interval between onset of spasm and therapy. Conclusion Increasing awareness in primary health care providers regarding infantile spasms will result in better seizure control and psychomotor development.