Abstract
Introduction: The care of diabetic wounds in the hospital setting presents a unique challenge for many physicians. These difficult-to-close wounds cost billions of dollars in hospital stay and surgical interventions. Vacuum Assisted Closure (VAC®) hastens wound closure and has gained widespread acceptance. Diabetes is marked by a prolonged inflammatory period, elongating time to recovery. During this time, wound healing is marked by the presence of pro-inflammatory cytokines (i.e., Il-1-β), growth factors (i.e., TGF- β) and metalloproteinases (i.e., MMP-13).
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